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Kurt Warner has thrown for at least two touchdowns in 12 of his last 13 games.

It was over when ...
The Cardinals made the Bills pay for turning the ball over for the third time. After Arizona recovered quarterback J.P. Losman's fumble, RB Tim Hightower scored on a 2-yard run, putting the team up 41-17 with 10:35 left in the fourth quarter.

Game ball
Arizona QB Kurt Warner was nearly flawless, completing 33 of 42 passes for 250 yards and two touchdowns. Warner distributed the ball to nine different receivers and directed an offense that sustained long scoring drives and was only forced to punt twice.

Key stat
The Bills defense was on the field for more than 35 minutes of game time. Arizona made nine third-down conversions and was able to put together drives of 14, 13 and 12 plays, all of which led to touchdowns.

Noteworthy
Bills starting QB Trent Edwards suffered a concussion on the third play of the game and was replaced by Losman. ... The Bills hadn't played in Arizona since 1999. ... The Cardinals have won five straight at home, where they are 8-2 under Ken Whisenhunt. ... The Cardinals have scored 76 points in the last two games, second-most in team history.