The Buffalo Bills have released their eight-figure man. Almost four years after signing a $96-million contract, former No. 1 overall pick Mario Williams has been released by the Bills.

Nursing a nagging hamstring injury, Buffalo Bills running back LeSean McCoy is unlikely to play this week against the New York Giants, according to Rand Getlin.

The first week of fantasy season is underway, and a wild Sunday it was. The NFL Fantasy staff recaps every game so you can quickly catch up on all of the action.

Will Randall Cobb and LeSean McCoy be ready to play Week 1, or will their injuries keep them sidelined? We have all of the injury updates you need to know about your favorite fantasy stars.

Broncos wideout Emmanuel Sanders is still sidelined by a hamstring injury. It's possible he could miss the entire preseason as he hasn't practiced in almost three weeks.

LeSean McCoy took some goal line carries during the Buffalo Bills recent practice. Coach Rex Ryan said the tailback is more than just a shake and back runner.

Is Vernon Davis at risk of being cut by the 49ers before the season? Read who else makes Gregg Rosenthal's list of potentially surprising training camp cuts.

Minnesota Vikings fans will have to wait until the regular season to see Adrian Peterson. The running back is not expected to play during the preseason.

Bills running back Fred Jackson says Buffalo wants to get LeSean McCoy "300-plus carries next year." How will Rex Ryan balance his feared rushing attack?

Fantasy Roster Reset takes a look at the AFC East to see which new faces could make an impact for your fantasy squad in 2015. There's a new running back in Buffalo that's sure to fit that ... Bill.

Rex Ryan wants to give LeSean McCoy plenty of carries in 2015. Not so fast, though -- Fred Jackson has no plans to just hand over the starting gig. Find out what the longtime Bills running back had to say.

With so many proven running backs switching zip codes in free agency, who helped themselves the most? Find out that answer and more in our weekend's takeaways.

The Philadelphia Eagles deemed LeSean McCoy expendable Tuesday, agreeing to trade the All-Pro rusher to the Buffalo Bills. Bucky Brooks explains why Philly's loss is a huge win for Rex Ryan and Co.

With free agency set to begin next month, C.J. Spiller's time with the Bills could be nearing an end. Where does that leave Buffalo's running back situation heading into next season?

Niners GM Trent Baalke expressed hope after last season in re-signing Frank Gore, but the hard-charging running back isn't so sure San Francisco's front office is behind him.

Buffalo Bills coach Doug Marrone told reporters on Monday that running back C.J. Spiller (broken collarbone) remains on schedule to make a Week 16 return to the lineup.

It's been a whirlwind week for the city of Buffalo and its Bills. Learn what coach Doug Marrone and players said after the team's first practice in Detroit ahead of its game against the New York Jets.

The Bills canceled practice for a second consecutive day Thursday. With doubt creeping in on the viability of a Sunday kickoff, the NFL announced that it's continuing to work with the Bills and local authorities.

Another week, another viewer's guide courtesy of Kevin Patra. What are the key storylines you should keep an eye on this week? The fact that Cam Newton has been playing hurt, for starters.

Fred Jackson returned early from a groin injury last week. This week, the Bills running back will sit out his "Thursday Night Football" matchup on NFL Network against the Dolphins.

The Buffalo Bills could be sans two playmakers for Sunday's pivotal clash against the Chiefs as Sammy Watkins and Fred Jackson both are questionable. Here's the latest on the Week 10 injury report.

Coach Doug Marrone told reporters Thursday that veteran running back Fred Jackson is "not ready yet" to play despite practicing both Wednesday and Thursday.

In this Week's Like/Dislike Adam Rank reveals some Danger Zone picks for Week 10. Plus, find out why Roddy White is a good play and why Rueben Randle should stay on your bench this week.